Speaking at the World Economic Forum in Davos, Switzerland, they said the 10-year program will focus on vaccines for AIDS, tuberculosis, rota virus and pneumonia.
"We must make this the decade of vaccines," said Bill Gates.
"Vaccines are a miracle," added Melinda Gates. "With just a few doses, they can prevent deadly diseases for a lifetime. We've made vaccines our priority at the Gates Foundation because we've seen firsthand their incredible impact on children's lives."
Since stepping down as chief executive officer of Microsoft in mid-2008, Bill Gates has devoted most of his time to the Bill and Melinda Gates Foundation, a philanthropic organization he set up with his wife Melinda. He remains part-time chairman of the software giant.
The foundation directs most of its attention to global health, education and agriculture in the third world and has committed more than $21 billion since it was established in 1994.
The $10 billion commitment is the largest pledge ever made by a charitable foundation to a single cause, according to The Chronicle of Philanthropy, a newspaper covering nonprofit organizations.
The couple told delegates at Davos that they used a model developed by a consortium at the Johns Hopkins Bloomberg School of Public Health in the United States to project the potential impact of vaccines on childhood deaths over the next decade.
"By significantly scaling up the delivery of life-saving vaccines in developing countries to 90 percent coverage -- including new vaccines to prevent severe diarrhea and pneumonia -- the model suggests that we could prevent the deaths of some 7.6 million children under 5 from 2010-2019."

